of blood flow
What is Tricuspid Regurgitation?
Tricuspid regurgitation (TR) is a disorder in which the heart’s tricuspid valve does not close properly, causing blood to flow backward (leak) into the right upper heart chamber (atrium) when the right lower heart chamber (ventricle) contracts, reducing its efficiency. Severe TR affects more than 1.6 million patients in the U.S. today.
The onset of tricuspid regurgitation may be due to a structural change of components of the tricuspid valve apparatus, a lesion can be primary (intrinsic abnormality) or secondary/functional (right ventricular dilatation).
What are Symptoms of Tricuspid Regurgitation?
Tricuspid regurgitation may not cause any symptoms if the regurgitation is not severe. However, patients may experience:
- Active pulsing in the neck veins
- Decreased urine output
- Fatigue, tiredness
- General swelling
- Swelling of the abdomen
- Swelling of the feet and ankles
Treatment Options for Tricuspid Regurgitation
- Surgical Valve Repair – Your surgeon may perform valve repair by separating tethered valve leaflets, by closing holes (fenestrations) in leaflets and by reshaping the valve leaflets so that they can make contact with each other and prevent backward flow.
- Surgical Valve Replacement – If your tricuspid valve cannot be repaired, your surgeon may replace it with a biological or mechanical valve. In tricuspid valve replacement, your surgeon replaces the valve by removing part of the deformed valve and inserting a biological tissue (bioprosthetic) valve.
- Medical Management – For patients who are at high risk for surgery, the standard of care to treat TR is medical management. Unfortunately, this treatment option is ineffective and may result in complications that can lead to multiple re-hospitalizations. There is a significant unmet clinical need for a percutaneous solution to treat TR.